Thursday, January 26 LIVE WEBINAR: Control-Alter-Delete: Epigenetic regulation by non-coding RNAs in neuronal systems
Presented by: Dr. Jeremy Day, Assistant Professor in the Department of Neurobiology at the University of Alabama
Abstract of Presentation: Emerging evidence suggests that non-coding RNAs can interact with epigenetic modifiers to both recruit and suppress epigenetic mechanisms, and that this functions can be regulated by activity states of neurons. Register today to join Dr Day as he highlights his recent work exploring how non-coding RNA species regulate DNA methylation in neuronal systems, including interactions between non-coding RNAs and DNA methyltransferases and genome-wide characterization of non-coding RNAs that arise from protein-coding genes , and reviews the functional modulation of non-coding RNAs in memory formation and behavior.
Wednesday, February 1 LIVE WEBINAR: Epithelial Mesenchymal Transition (EMT) in carcinoma
Presented by: Professor Jean Paul Thiery, Research Director Emeritus at the Institut Gustave Roussy, Comprehensive Cancer Center at Villejuif,and at the CNRS unit Matter and Complex Systems, Visiting Professor, School of Medicine of National University of Singapore (NUS), and at CCBIO University of Bergen
Abstract of Presentation: This webinar will review recent data on adhesive mechanisms involved in the maintenance of an epithelial state versus the transition to a mesenchymal-like phenotype, as well as discuss a number of studies in support of the concept that EMT contributes to tumor progression. Register today to join Professor Jean Paul Thiery, Research Director Emeritus at the Institut Gustave Roussy Comprehensive Cancer Center at Villejuif for this live webinar and Q&A session.
Thursday, February 2 LIVE WEBINAR: Targeting axonal transport in Alzheimer's disease
Presented by: Elizabeth Glennon, Ph.D, Alzheimer's Research UK fellow, Institute of Psychiatry, Psychology and Neuroscience at King's College London
Abstract of Presentation: Disruption of axonal transport is an early event in several neurodegenerative diseases. For this reason, it is a potential target for drug discovery. Register today to hear Dr Glennon discuss this exciting topic in Alzheimer's research including, how the disruption of axonal transport contributes to the development of Alzheimer's disease, and the mechanisms of axonal transport of the Alzheimer's amyloid precursor protein, and how these are altered in the disease.
Caitlin's Master's thesis focused on age-related changes in mesenchymal stem cells using a murine model. She is a current member of the Histochemical Society and the International Society for Stem Cell Research.
John spent his graduate studies looking into exocystosis, and his post-doctoral years studying the process of synaptogenesis. He has used a variety of western blotting, immnuofluorescence and ELISA based applications to study these processes.
Jeremy joined the Neurobiology faculty at UAB in 2014, where his lab investigates the neurobiology of reward- related memory systems in the brain and the role of these circuits in motivated behaviours. His research integrates molecular, physiological, behavioral, genetic and epigenetic tools to understand how experience alters epigenetic states in the brain- with specific interest in the role of non-coding RNAs within this process.
His ultimate goal is to manipulate epigenetic or transcriptional patterns within selected neuronal populations to achieve therapeutic outcomes from the brain diseases. His work is supported by research grants from the National Institute on Drug Abuse, the Pittman Scholars Program, and by the Evelyn McKnight Brain Institute.
Dr Lee is currently a principal investigator at the Cambridge Stem Cell Institute, at the University of Cambridge, UK. Together with her group, she focuses on understanding the cellular behavior and regulatory networks of adult stem and niche cells in homeostasis and regeneration.
Since 2006, Cristina has been led the Cell Death Regulation Group at the Division of Molecular Oncology in the Bellvitge Biomedical Research Institute (IDIBELL) in Barcelona, Spain. The main interest of her team is to understand why and how cells die when deprived of nutrients in the context of cancer and brain ischemia.
Andrew completed his postdoctoral training at St. Jude Children's Research Hospital in Memphis, TN, and in 2012 he joined the University of Washington's Department of Immunology as an Assistant Professor. Dr Oberst's research focuses on understanding the pathways of programmed cell death, and how different forms of cell death are perceived by the immune system.
In 1999, Dr Prendergast became Senior Director of Cancer Research at DuPont Pharmaceuticals. In 2002, his research groups moved from Wistar and DuPont to the Lankenau Institute for Medical Research outside Philadelphia, where he is currently Professor, President and CEO. In 2010, Dr Prendergast was appointed Editor-in-Chief of Cancer Research, the AACR flagship journal, and the most highly cited journal in the field.
Dr Alejandra Solache joined Abcam in 2013 as Head Reagents Product Development and Manufacturing globally. She is responsible for managing the output of the Abcam Cambridge, Hangzhou and Bristol laboratories, specifically the New Product Development, Core reagents and R&D. She also plays a key role in developing Abcam’s innovation strategy.
Prior to joining Abcam she held various positions at EMD-Millipore, latterly as R&D Director, leading the Antibody and Assay Development teams. She gained expertise in Immunology, cell signaling and cell biology through postdoctoral fellowships at UCSF and the Trudeau Institute.
Jean Paul serves as a Scientific Advisor of the Dean of Medical School NUS, Singapore, and in a number of other Institutions worldwide. He was until June 2015, Professor and Head of the Biochemistry Department, School of Medicine at NUS. He has also served a joint appointment as Research Director at IMCB A*STAR Singapore, and Senior Principal Investigator at the Cancer Science Institute at NUS.
Jean Paul is credited as the first to propose that EMT control invasion and dissemination while the reverse process, MET, is required for the development of clinically detectable metastases in carcinoma. His current research's focus is to unravel the mechanisms of invasion and metastasis of carcinoma cells, while his seminal contributions to bladder carcinoma studies have led to the discovery of the molecular mechanisms underlying the formation of superficial or invasive tumors. Currently, his research is focusing on oncogenomics and the creation of functional approaches to characterize bladder, lung breast, and ovarian carcinoma progression- with the ultimate goal to apply EMT-based therapeutic approaches in the near future.
He is an EMBO and Academia Europea member. He has been made Chevalier (Knight) in the order the Legion d'Honneur , the highest distinction in France, in 2009.
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